Abstract
Cathelicidins are natural antimicrobial peptides synthesized and stored in neutrophils, macrophages and also in epithelial cells of gut, skin, cornea and lungs.1, 2, 3, 4 Cathelicidins are present in all mammalian species and exert a potent, broad-spectrum antimicrobial activity against bacteria, viruses, fungi and some parasites by disrupting the membranes of these microorganisms.1, 2, 3 In mice, the cathelicidin cathelin-related antimicrobial peptide (CRAMP) is encoded by the gene Cnlp. In humans, the cathelicidin LL-37 is encoded by the gene camp.1, 2, 3, 5
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