Abstract
Objective: The present study was aimed to determine whether the ethanolic extract of Garcinia mangostana (mangosteen) fruit pericarp (EEMP) changes several markers of inflammation, such as nuclear factor kappaB (NF-κB) p65/p50 distribution, tumor necrosis factor (TNF)-α levels, and nitric oxide (NO) in the atherosclerotic rats model. Methods: Thirty male Wistar rats were divided into five groups (n = 6 each), including standard diet (control group), hypercholesterolemic diet (HD) group, HD + EEMP at dose of 200, 400 and 800 mg/kg body weight (BW). Analysis of NF-κB p65/p50 distribution was done by imunnohistochemistry method. The levels of TNF-α and NO were measured by ELISA. Results: High cholesterol diet significantly increased NF-κB p65/p50 distribution, TNF-α levels and NO levels compared with control group. The levels of NF-κB p65/p50 distribution was significantly decreased in EEGM-treated group at doses 200 and 800 mg/kg BW than that in atherosclerosis group. The levels of NO and TNF-α were significantly decreased in EEGM-treated group at all doses compared to atherosclerosis group, but did not reach levels at standard diet. Conclusions: The present data suggests that EEMP inhibits inflammation in atherosclerotic rats due to inhibition of distribution NF-κB p65/p50 into the nucleus and decreases TNF-α and NO levels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
