Catfish Taguchi-Based Binary Differential Evolution Algorithm for Analyzing Single Nucleotide Polymorphism Interactions in Chronic Dialysis.

Abstract

Single-nucleotide polymorphism (SNP)-SNP interactions are crucial for understanding the association between disease-related multifactorials for disease analysis. Existing statistical methods for determining such interactions are limited by the considerable computation required for evaluating all potential associations between disease-related multifactorials. Identifying SNP-SNP interactions is thus a major challenge in genetic association studies. This paper proposes a catfish Taguchi-based binary differential evolution (CT-BDE) algorithm for identifying SNP-SNP interactions. In the search space, the catfish effect prevents the premature convergence of the population, and the Taguchi method improves the search ability of the BDE algorithm. Hence, the proposed algorithm enables obtaining a favorable solution regarding the identification of high-order SNP-SNP interactions. Additionally, the proposed algorithm applies an effective fitness function derived from a multifactor dimensionality reduction (MDR) operation to evaluate the solutions from BDE-based algorithms. Simulated and real data sets were used to evaluate the ability of several BDE-based algorithms in identifying specific SNP-SNP interactions. We compared the fitness function derived from the MDR operation with that derived according to the difference between cases and controls, by using the different BDE-based algorithms. The results showed that the proposed CT-BDE algorithm applying the fitness function derived from the MDR operation exhibited a superior ability in identifying SNP-SNP interactions compared with the other BDE-based algorithms.