Catecholaminergic and neuropeptide Y-immunoreactive synaptic inputs onto median preoptic nucleus neurons projecting to the ventrolateral medullary catecholaminergic area in the rat

Abstract

Median preoptic nucleus (POMe) neurons are innervated by catecholaminergic and neuropeptide Y (NPY)-immunoreactive nerve terminals originating from the catecholamine area of the ventrolateral medulla (VLM). The possibility that such POMe neurons project to the VLM catecholamine area was investigated in the rat. Immunoelectron microscopy revealed synaptic contacts of tyrosine hydroxylase- and NPY-immunoreactive axon terminals onto POMe neurons retrogradely labeled from the VLM catecholamine area, suggesting the existence of bidirectional connections between these two regions.