Abstract
1. Using the voltage-clamp technique catecholamine-induced hyperpolarization has been shown to be accompanied by outward currents. 2. The currents do not reverse even at membrane potential shift to −150 mV. 3. The catacholamine-induced currents are inhibited by strophanthidine, lowering the temperature and substitution of external Na + by Li +. 4. The similarity between potential dependences of catecholamine-induced currents and the strophanthidine-sensitive part of membrane potential has been found. 5. The results strongly suggest catecholamines stimulate Na + −K +-pump in the neurones studied.
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