Abstract

 The preoperative anxiety’s incidence is very high and mostly preoperative patients have anxiety. It was found that low COMT levels indicate a tendency to develop anxiety. Hence, this study aims to investigate COMT enzyme levels in patients with preoperative anxiety. This research is a purely experimental research with a pretest-posttest control group design and double-blind. Measurement of COMT enzyme levels was executed by utilizing ELISA technique. Blood samples were taken from preoperative anxiety patients who were assessed with the Amsterdam Preoperative Anxiety Information Scale (APAIS). The research was carried out at Haji Adam Malik General Hospital and Regional General Hospital dr. Pirngadi Medan, and Integrated Laboratory of the Faculty of Medicine, University of North Sumatra. The were 64 samples involved in this research that fit the inclusion and exclusion criteria. The findings show that COMT levels in the anxiety and control groups had differences with p values = 0.014. In addition, COMT levels in the preoperative anxiety group were lower when compared to those without the preoperative anxiety group, where in the anxiety group had COMT enzyme levels of 0,14 ± 0,08 ng/dl, while in the control group had higher COMT levels 0,96 ± 1,11 ng/dl. The results showed that patients with preoperative anxiety had lower levels of the COMT enzyme compared to patients without preoperative anxiety. Researchers suspect there is a role for the COMT enzyme in causing preoperative anxiety.
 
 
 
 
 
 
 
 
 
Highlights
Anxiety is extremely common among individuals undergoing preoperative treatments
Preoperative anxiety affects approximately 82% of patients, with a higher percentage seen in patients getting general anesthesia compared to those undergoing regional anesthesia, and in female patients compared to male patients (Mitchell, 2013)
In the preliminary study conducted at the Haji Adam Malik General Hospital (HAM) which involved 121 patients planned to undergo elective surgery, the preoperative anxiety, which was measured with Amsterdam Preoperative Anxiety Information Scale (APAIS) score, and found to be very high, which was 48.3% (Tinambunan et al, 2019)
Summary
Preoperative anxiety affects approximately 82% of patients, with a higher percentage seen in patients getting general anesthesia compared to those undergoing regional anesthesia, and in female patients compared to male patients (Mitchell, 2013). In the preliminary study conducted at the Haji Adam Malik General Hospital (HAM) which involved 121 patients planned to undergo elective surgery, the preoperative anxiety, which was measured with APAIS score, and found to be very high, which was 48.3% (Tinambunan et al, 2019). Procedure-related factors such as major surgery, chronic illness, and unscheduled emergency procedures play an important role in the emergence of anxiety in preoperative patients. Information on preoperative anesthesia, adverse effects of anesthesia, and sudden surgery recommendations statistically have been shown to be significantly related to overall anxiety increase (Celik & Edipoglu, 2018)
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