Abstract
Less than a decade after Julius Axelrod initially described catechol-O-methyltransferase (COMT) (1), an enzyme he had isolated from rat liver to elaborate epinephrine metabolism, Angelo DiGeorge first hinted at a congenital clinical syndrome of hypoparathyroidism and absence of the thymus (2). There is no reason to suspect that these contemporaries, ensconced in entirely different fields and approaches, would have made particular note of each other’s work, much less anticipated that their respective discoveries might inextricably converge half a century later in the modern era of psychiatric genetics.
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