Abstract
The effect of catechol on the fast voltage-gated K + current ( I K(f) of acutely dissociated rat melanotrophs was investigated in whole-cell recordings. Half-maximal inhibition of I K(f) occurred at an external concentration of 1.7 mM and this effect was associated with a decrease of the rate of the current decay. Internal catechol had no measurable effect on I K(f). Catechol appeared to be equally effective as a blocker of the slow voltage-gated K + current ( I K(s)). Despite this lack of specificity the blocking action of catechol was voltage- and frequency-independent and was rapidly reversible. Catechol therefore represents a useful alternative to 4-aminopyridine as a blocker of I K(f).
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