Abstract
The effect of catechol on the fast voltage-gated K + current ( I K(f) of acutely dissociated rat melanotrophs was investigated in whole-cell recordings. Half-maximal inhibition of I K(f) occurred at an external concentration of 1.7 mM and this effect was associated with a decrease of the rate of the current decay. Internal catechol had no measurable effect on I K(f). Catechol appeared to be equally effective as a blocker of the slow voltage-gated K + current ( I K(s)). Despite this lack of specificity the blocking action of catechol was voltage- and frequency-independent and was rapidly reversible. Catechol therefore represents a useful alternative to 4-aminopyridine as a blocker of I K(f).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
