Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury.

Lúcio Ricardo Leite Diniz,Marilia Trindade De Santana Souza,Allana Brunna Sucupira Duarte,Sabarno Datta,Damião Pergentino De Sousa,Hatem A Elshabrawy

doi:10.3390/molecules26195951

Lúcio Ricardo Leite Diniz, Marilia Trindade De Santana Souza + Show 4 more

Open Access

https://doi.org/10.3390/molecules26195951

Copy DOI

Abstract

Data obtained from several intensive care units around the world have provided substantial evidence of the strong association between impairment of the renal function and in-hospital deaths of critically ill COVID-19 patients, especially those with comorbidities and requiring renal replacement therapy (RRT). Acute kidney injury (AKI) is a common renal disorder of various etiologies characterized by a sudden and sustained decrease of renal function. Studies have shown that 5–46% of COVID-19 patients develop AKI during hospital stay, and the mortality of those patients may reach up to 100% depending on various factors, such as organ failures and RRT requirement. Catechins are natural products that have multiple pharmacological activities, including anti-coronavirus and reno-protective activities against kidney injury induced by nephrotoxic agents, obstructive nephropathies and AKI accompanying metabolic and cardiovascular disorders. Therefore, in this review, we discuss the anti-SARS-CoV-2 and reno-protective effects of catechins from a mechanistic perspective. We believe that catechins may serve as promising therapeutics in COVID-19-associated AKI due to their well-recognized anti-SARS-CoV-2, and antioxidant and anti-inflammatory properties that mediate their reno-protective activities.

Highlights

Coronaviruses (CoVs) are positive single-stranded (+ss) RNA viruses that are known to infect several mammalian and avian species [1,2]
In December 2019, SARS-CoV-2 was identified as the novel causative agent of Coronavirus Disease 2019 (COVID-19) that originated in Wuhan, China, and later became a pandemic, resulting in millions of deaths worldwide [4]
We review the anti-SARS-CoV-2 activity of catechins, safety and effectiveness of catechins in Acute kidney injury (AKI) induced by diverse nephrotoxic stimuli, and provide evidence that catechins could be used as antiviral and reno-protective agents to prevent

Summary

Introduction

Coronaviruses (CoVs) are positive single-stranded (+ss) RNA viruses that are known to infect several mammalian and avian species [1,2]. Patients on dialysis with earlier-stage renal disease requiring RRT have become a vulnerable group to COVID-19-related morbidity and mortality, and it is extremely necessary to find an effective treatment for impairment of renal functions and damages promoted by SARV-CoV-2 infection. In this context, reno-protective compounds that showed therapeutic activity in different experimental models of AKI and antiviral activity against SARS-CoV-2 would be ideal in COVID-19-associated AKI [29].

Materials and Methods

Catechins

Anti-SARS-CoV-2

Reno-Protective Effect of Catechins in the Acute Kidney Injury

Conclusions