Catathrenia in severe obstructive sleep apnea: A novel entity never described before

Abstract

Study objectivesCatathrenia, derived from the Greek κατά (kata) meaning below and θρηνώ (threnia) to lament, is characterized by expiratory groaning episodes during sleep. In a case series of nine patients with severe obstructive sleep apnea, we observed a peculiar groaning entity that has not been described before. MethodsWe described and illustrated the cases with polysomnographic tracings and additional audio recordings. ResultsAll patients were men, obese (body mass index 39 ± 6 kg/m2) with an apnea-hypopnea index ranging from 47 to 125/h. In addition, we identified groaning events that were consistently preceded by a cortical arousal associated with a “rescue” respiration after an obstructive hypopnea or apnea. These events exhibited characteristics of “mixed apnea’s”, but the “central apnea-like part” was a prolonged expiratory groaning phase, with immediately after the terminal expiratory snort appearance of an obstructive apnea. In case the duration of this expiration was at least 10 s we calculated these events separately and the index was 8.4 ± 7.7/h. More rarely (index 0.6 ± 0.5/h) a “central apnea mimicking event” with groaning not followed by an obstruction, was observed. We also observed groaning episodes during expiration with a shorter duration (less than 10 s), not calculated separately. Positive airway pressure, which was well tolerated, eliminated these events. ConclusionsThis novel catathrenia entity preceded by a cortical arousal and “rescue” respiration in response to obstructive events is intriguing. Possible explanations for these observations are further discussed in this article.