Cataract type and pupillary response to blue and white light stimuli

Manami Kuze,Toshiyuki Koyasu,Kazuo Tsubota,Mineo Kondo,Masahiko Ayaki,Kazuno Negishi

doi:10.1038/s41598-020-79751-8

Manami Kuze, Toshiyuki Koyasu + Show 4 more

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https://doi.org/10.1038/s41598-020-79751-8

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Abstract

We evaluated the pupil reaction to blue and white light stimulation in 70 eyes with cataract and in 38 eyes with a selective blue-light filtering intra-ocular lens. The diameter of the pupil before stimulation was set as baseline (BPD) and, after a stimulus duration of 1 s, the post-illumination pupillary response (PIPR) was measured using an electronic pupillometer. The BPD showed no significant difference among three grades of nuclear sclerosis (NS). In contrast, the PIPRs differed significantly among the NS grades eyes including with and without subcapsular cataract (SC) and IOL eyes for white light (p < 0.05, Kruskal–Wallis test), but not for blue light. Subcapsular opacity did not affect the BPD or PIPR in all cataract grades for either light stimulus. The tendency of larger PIPR in the pseudophakic eyes than the cataract eyes for both lights, however significant difference was found only for white light (p < 0.05 for white light, p > 0.05 for blue light). Our study demonstrates retention of the PIPR for blue light, but not for white light in cataract eyes. We also confirmed that the pupillary response in pseudohakic eyes with a selective blue light-filtering intra ocular lens was greater than that in cataractous eyes for white light.

Highlights

We evaluated the pupil reaction to blue and white light stimulation in 70 eyes with cataract and in 38 eyes with a selective blue-light filtering intra-ocular lens
Light transmittance decreases with aging crystalline lenses and the magnitude of light-evoked pupillary responses are reduced[23]
The first to investigate the pupillary responses in eyes with various types of cataracts (NS and/or subcapsular cataract (SC)) and in eyes with selective blue-light filtering intra-ocular lenses (IOLs), we found that the post-illumination pupil response (PIPR) to blue light in nuclear sclerosis (NS) may maintain its amplitude despite the disturbance in transmission, as well as aging

Summary

Introduction

We evaluated the pupil reaction to blue and white light stimulation in 70 eyes with cataract and in 38 eyes with a selective blue-light filtering intra-ocular lens. We confirmed that the pupillary response in pseudohakic eyes with a selective blue light-filtering intra ocular lens was greater than that in cataractous eyes for white light. Differ in morphology and project to different brain a reas[18], and these inner retinal photoreceptors are thought to have the entire role of driving the post-illumination pupil response (PIPR)[19,20,21]. This sustained pupil constriction after a light stimulus matches the spectral sensitivity of the melanopsin pigment, making it useful as a direct biomarker of ipRGC function[20,21,22]

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