Abstract
An efficient La2O3-catalyzed new route for the carbon-carbon bond formation in particular, symmetrical and unsymmetrical biphenyls has been developed, which proceeds through carbon-carbon coupling reaction of aryl iodides with boronic acids. The reaction provided the desired products in moderate-to-good yields with a wide range of functional group tolerance.
Highlights
The formation of new carbon-carbon bonds is of central importance in organic and medicinal chemistry [1, 2]
The outer electron configuration of the transition and noble group metals made them the most frequently used catalysts [24]. These metal oxides have been proved as efficient catalysts for the coupling reaction
The reaction mixture was heated to 150◦C and the progress of reaction was monitored by TLC
Summary
The formation of new carbon-carbon bonds is of central importance in organic and medicinal chemistry [1, 2]. The development of new methods for carbon-carbon bond formation is a well-growing area in organic chemistry [3]. The transition metals have played an important role in organic chemistry and this has led to the development of a large number of transition metal-catalyzed reactions for the formation of C–C and carbon-heteroatom bonds in organic synthesis [5, 6]. The outer electron configuration of the transition and noble group metals made them the most frequently used catalysts [24]. These metal oxides have been proved as efficient catalysts for the coupling reaction. We have developed a La2O3 catalyzed C–C coupling by using aryl halide and boronic acids
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