Abstract
A series of imine-based covalent organic frameworks decorated in their cavities with different alkynyl, pyrrolidine, and N-methylpyrrolidine functional groups have been synthetized. These materials exhibit catalytic activity in aqueous media for the hydrolytic detoxification of nerve agents, as exemplified with nerve gas simulant diisopropylfluorophosphate (DIFP). These preliminary results suggest imine-based covalent organic frameworks (COFs) as promising materials for detoxification of highly toxic molecules.
Highlights
Nerve agents are amongst the most toxic chemical compounds known to mankind as a consequence of their easy penetration through human mucosa and ulterior damage of the central nervous system by the inhibition of acetylcholinesterase (AChE) [1]
We have considered considered that that the the porous porous framework framework structure structure and and precise precise location location of of catalytically active sites in the porous structure of a can be useful for the introduction of nerve catalytically active sites in the porous structure of a covalent organic frameworks (COFs) can be useful for the introduction of nerve agent anan imine-based agent hydrolytic hydrolyticdetoxification detoxificationfunctions
The syntheses of the COFs endowed with pyrrolidine moieties start with the synthesis of an alkynyl-functionalized COF ([HC≡C]0.5-TPB-DMTP-COF, Scheme 1) by following a procedure previously described [25,40]
Summary
Nerve agents are amongst the most toxic chemical compounds known to mankind as a consequence of their easy penetration through human mucosa and ulterior damage of the central nervous system by the inhibition of acetylcholinesterase (AChE) [1]. Protection and decontamination of these toxic chemicals is a very important societal challenge. Their hydrolytic degradation under environmental conditions (room temperature and ambient moisture) is one of the most convenient detoxification pathways, it will only take place in the presence of a suitable catalyst. Such catalyst should be a porous solid combining adsorptive and catalytic properties
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