Catalytic trifluoromethylation of aldehyde and potential application for pyrano[4,3-b]quionline synthesis

Abstract

We have described CsF-catalyzed trifluoromethylation of heteroaromatic aldehydes at room temperature to afford trifluoromethyl group containing alcohols in very good yields. Using catalytic amount of CsF (0.2 eq.) in toluene, trifluoromethylated products were achieved in good yields at rt. The substrate scope has been exemplified by a large number of substrates. As an application, iodo etherification/cyclization has also been demonstrated for the synthesis of trifluoromethyl pyrano[4,3-b]quinoline from o-alkynyltrifluoro methyl alcohol, in very good yield.