Abstract
<p indent=0mm>RNA polymerase II transcribes all protein-coding genes and many noncoding RNAs in eukaryotes. POLR2A is the key catalytic subunit of RNA polymerase II that plays an irreplaceable role in gene expression. The expression regulation of POLR2A itself is vital for gene transcription in cells. Recent studies have also shown that POLR2A is closely related to many diseases, including tumors. This review focuses on the expression regulation of POLR2A itself, covering the transcription levels, pre-mRNA splicing, mRNA stability, and protein degradation, and summarizes the role of POLR2A in tumors and other diseases, as well as the progress of tumor therapy targeting POLR2A.
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