Abstract
The catalytic behaviour of several Ru, Rh and Ir systems containing bis(oxazoline) ligands ( 1– 6) has been tested in the asymmetric reduction of acetophenone ( 7) to give 1-phenylethanol ( 8) by hydrogenation (Ir systems), transfer hydrogenation (Ir and Ru systems) and hydrosilylation (Ir and Rh systems). Ligands 1 and 3 gave good activities, obtaining the best asymmetric induction with Ir– 1 system in the hydrosilylation (ee up to 50% ( S) of 8). In order to identify the catalytic precursors, Ru ( 9– 11) and Ir ( 12) complexes were synthesised and characterised. NMR studies of ruthenium complexes showed the existence of two main isomers in a ca. ratio 3/1, in agreement with the PM3(tm) calculations carried out for 10.
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