Catalytic potential of sustainable dinuclear (Cu2+ and ZrO2+) metal organic incorporated frameworks with comprehensive biological studies

Abstract

BackgroundThe high coordination ability of dihydrazone derivatives with metals of different valents, new homo dinuclear complexes of low and high valent ions of Cu2+ and ZrO2+ (CuLss and ZrOLss, respectively) were constructed via their coordination with diisatin succinyldihydrazone ligand (H2Lss). In which, the structure confirmation of H2Lss and its MLss complexes were achieved by different distinguished spectral tools. MethodsThe two novel MLss complexes were constructed by 2: 1 molar amounts of M2+ (Cu2+ or ZrO2+) ion to the H2Lss mole in DMF. Their catalytic action was examined under aerobic and homogeneous phase in the productive benzyl alcohol redox protocol within an aqueous H2O2. The antimicrobial and anticancer activities of H2Lss, CuLss and ZrOLss were investigated. In addition, their interaction with calf thymus DNA (ctDNA) was studied through spectrophotometric and viscometric techniques. The significant findingsAppreciable productivity was recognized with the yielded amounts of benzaldehyde (the corresponded selective oxide product) with both catalysts. However, CuLss represents more classified action by 92% yielding of benzaldehyde (for about 5 h at reaction temperature 60 °C with 0.005 mmol of its loaded amount), whereas, ZrOLss showed less efficacy with 87% (for 3 h at temperature of the reaction 70 °C with 0.005 mmol loaded amount). The catalytic progress referred to the nature of metal ion, which could be interpreted in the catalytic mechanism, i.e. the oxygen transfer pathway. The two MLss complexes exhibited more significant inhibiting affect against the bacterial and fungal strains and as well as the cancer cell lines than those of the free H2Lss, pointing to the function of M2+ ion in their MLss complexes. CuLss showed more interaction potential with ctDNA more than that of ZrOLss according to the Kb, the binding constants, (= 16.51 and 14.37 × 107 mol−1.dm3), also on the derived values of the Gibbs’ free energy values (ΔGb≠ = -46.39 and -45.61 kJ.mol−1), respectively, however, both CuLss and VOLss exhibited higher reactivity over their H2Lss (Kb = 10.87 × 107 mol−1.dm3 and ΔGb≠ = -43.75 kJ.mol−1) referring to the type and nature of interaction depending on the M2+ ion to progress their reactivity towards ctDNA.