Catalytic Enantioselective Reduction of β,β‐Disubstituted Vinyl Phenyl Sulfones by Using Bisphosphine Monoxide Ligands

Abstract

Synthesis of chiral sulfones: A copper–phosphine complex efficiently provided optically active alkyl phenyl sulfones by hydrosilylation at room temperature. The reduction of β,β-disubstituted vinyl sulfones in the presence of the Me-DuPhos monoxide ligand lead to excellent enantiomeric excesses and high yields (see scheme). The prepared chiral sulfones were desulfonylated and subjected to Julia olefination conditions.