Abstract
AbstractAn efficient catalytic enantioselective Michael reaction has been developed using chiral palladium complexes. Various substrates including β‐keto esters and 1,3‐diketones reacted with α,β‐unsaturated carbonyl compounds to give the corresponding Michael adducts in good yield with up to 99% ee, thereby affording chiral quaternary carbon centers. In these reactions, chiral palladium enolates were generated as key intermediates, which acted cooperatively with a strong protic acid to activate the Michael acceptors for promotion of the CC bond‐forming reaction.
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