Abstract
Enamine catalysis enables the first catalytic enantioselective Friedländer reaction. The desymmetrization of 4-substituted cyclohexanones upon reaction with o-aminobenzaldehydes allows for the synthesis of quinolines with remote stereogenic centers. These heterocycles, which are obtained with high levels of enantioselectivity, serve as precursors for chiral tacrine analogues.
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