Catalytic Enantioselective Allenylation Reactions of Aldehydes with Tethered Bis(8-quinolinolato) (TBOx) Chromium Complex

Abstract

The utility of the new class of chiral ligand, tethered bis(8-quinolinol) (TBOxH), is further explored. Its chromium complex, TBOxCr(III)Cl, effectively catalyzes the asymmetric allenylation reactions of various aldehydes at room temperature with high yields (up to 91%) and high enantioselectivities (up to 97% ee). The scope of the present method is shown to be wide, and this method represents an efficient access to chiral α-allenic alcohols.