Abstract
A catalytic, enantioselective acetate-aldol addition reaction of silyl ketene acetals with α,β-ynals and 3 mol % of a chiral Ti(IV) complex is described. This process provides access to optically active β-hydroxy-γ-alkynyl esters in 84–96% yields and 94–97% ee's.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
