Catalytic desymmetrization of the mechanical bond

Abstract

In the October issue of Chem , Chong Tian, Ye Zhu, and co-workers describe a post-synthetic catalyst-controlled desymmetrization strategy for synthesizing mechanically planar chiral rotaxanes by relying on distal ionic interactions between a prochiral rotaxane and a novel anionic chiral phosphine ligand to trigger a desymmetrizing Pd-catalyzed Suzuki-Miyaura coupling. In the October issue of Chem , Chong Tian, Ye Zhu, and co-workers describe a post-synthetic catalyst-controlled desymmetrization strategy for synthesizing mechanically planar chiral rotaxanes by relying on distal ionic interactions between a prochiral rotaxane and a novel anionic chiral phosphine ligand to trigger a desymmetrizing Pd-catalyzed Suzuki-Miyaura coupling.