Abstract
NON-enzymatic decarboxylation of α-amino-acids was tried many years ago by heating them above 200° C., often dissolved or dispersed in an inert solvent too. As the reactions are always exotherm, heating is only required to reach the rather high energies of activation. The way in which Nature lowers these energies by enzymatic reactions has been frequently discussed. The formation of a Schiff's base between an α-amino-acid and pyridoxal-phosphate as the proved prosthetic group of most of the decarboxylases is postulated by many authors, and the easiness of their decarboxylation may be understood with the help of the electronic theory of valence.
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