Abstract
Abstract Palladium- and nickel-catalyzed coupling reactions have become a powerful method for the functionalization of alkenes and arenes. There is a broad variety of different reactions to choose from, which in many cases can be used to reach the same synthetic end-point. Moreover, in recent years many different procedures for each type of reaction have been published, making it even more difficult to choose the right procedure for a particular synthetic problem. The following chapter will provide the reader with procedures that are applicable to a large number of substrates. Nevertheless, if a protocol should not work for a specific case, it might be worth changing the reaction conditions—even if this change appears to be rather small—since palladium-and nickel-catalyzed reactions are quite sensitive towards parameters such as the palladium source, ligand, base, solvent, temperature, and substrate.
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