Abstract
We have previously described an autoantibody-catalyzed hydrolysis of vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide with airway smooth muscle relaxant and anti-inflammatory properties. 1 Paul S Volle DJ Beach CM et al. Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science. 1989; 244: 1158-1162 Crossref PubMed Scopus (386) Google Scholar Catalytic antibodies can be expected, by definition, to achieve more efficient inactivation of VIP than antibodies that bind the peptide stoichiometrically. Our aims here were the characterization of catalytic autoantibodies to VIP in asthma; and molecular cloning of catalytic anti-VIP antibody.
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