Abstract
A catalytic asymmetric synthesis of nitrogen-containing gem-bisphoshonates is described. A Lewis acid-Brønsted base bifunctional homodinuclear Ni2-Schiff base complex promoted catalytic enantioselective conjugate addition of nitroacetates to ethylidenebisphosphonates, giving products in up to 93% ee and 94% yield. Transformation of the product into a chiral α-amino ester with a gem-bisphosphonate moiety is also described.
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