Abstract
1. Reductive aminolysis of 2-trifluoromethyl-4-benzylidene-Δ2-oxazolin-5-one in the presence of S-amino acid esters, PdCl2 and H2 proceeds via the intermediate formation of RS-peptides. 2. Aminolysis of 2-trifluoromethyl-Δ3-oxazolin-5-ones with S-AlaOMe, S-ValOMe, S-PheOMe proceeds with a high stereoselectivity, with the formation of SS-diastereomer, so that optically pure SS-PheAla and SS-PhePhe dipeptides could be obtained. 3. Aminolysis of 2-trifluoromethyl-Δ3-oxazolin-5-ones with S-ProOMe preferentially gives RS-peptides.
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