Catalytic Asymmetric Mannich‐Type Reactions Using a Novel Chiral Iron Complex.

Abstract

Catalytic asymmetric Mannich-type reactions using a novel chiral iron complex have been developed. The reactions proceeded smoothly in the presence of a catalyst prepared from iron(II) chloride, a BINOL derivative, and i-Pr2NEt. The desired products were obtained in good yield with good to high enantioselectivity, when 3,3′-I2BINOL was employed as a chiral ligand. A protic additive such as methanol facilitated the reactions effectively.