Abstract
The first catalytic asymmetric inverse-electron demand [3 + 2]-cycloaddition of isoquinolinium methylides with enecarbamates has been realized by using a N,N′-dioxide/Ag(I) complex. The optically active pyrroloisoquinolines and pyrrolophthalazine were obtained in up to 99% yield, >19:1 d.r., and 95% ee. On the basis of fluorescence, ESI-MS analysis, and X-ray structure of the product, a reasonable transition state was proposed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
