Catalytic Asymmetric Domino Michael–Henry Reaction: Enantioselective Access to Bicycles with Consecutive Quaternary Centers by Using Bifunctional Catalysts

Abstract

Domino catalysis: Two consecutive quaternary stereocenters, three functional groups, and four stereogenic centers have been created in the newly developed domino Michael–Henry reaction (see scheme) employing small amounts of a bifunctional organocatalyst.