Abstract
Access to a chiral sulfone: Asymmetric conjugate reduction of β,β-disubstituted α,β-unsaturated 2-pyridylsulfones with silanes under CuI/binap catalysis provides chiral sulfones with excellent chemical yields and enantioselectivities (see scheme). These enantioenriched 2-pyridylsulfones are versatile intermediates in the preparation of a wide variety of functionalized chiral compounds. binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700296_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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