Catalytic asymmetric C2-nucleophilic substitutions of C3-substituted indoles with ortho-hydroxybenzyl alcohols

Abstract

Catalytic asymmetric C2-nucleophilic substitutions of C3-substituted indoles such as tryptophols or tryptamines with ortho-hydroxybenzyl alcohols have been established, leading to the generation of triaryl methane products in generally high yields and excellent enantioselectivities.