Abstract
A unique catalytic asymmetric C-7 Friedel-Crafts alkylation/N-hemiacetalization cascade reaction of 4-aminoindoles with β,γ-unsaturated α-keto esters has been described. Using a chiral magnesium H8-BINOL-derived bis(phosphate) complex as catalyst, the resulting functionalized 1,7-annulated indole scaffolds are obtained in high yields (up to 98%) and with good to excellent enantioselectivities (up to 99%) and diastereoselectivities (up to >20:1) under mild reaction conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
