Catalytic Asymmetric Amino Acid and Its Derivatives by Chiral Aldehyde Catalysis.

Kaijin Lin,Chunhong Shi,Jinbiao Lin,Honggui Lin,Ang Shi

doi:10.3389/fchem.2021.687817

Abstract

Amine acid transformation is an important chemical process in biological systems. As a well-developed and acknowledged tool, chiral aldehyde catalysis provides good catalytic activation and stereoselective control abilities in the asymmetric reaction of N-unprotected amino acid esters and amino acid esters analogs, in which the key to success is the design of the catalysts derived from chiral BINOL aldehyde, which is based on the face control of enolate intermediates. In this review, one of the co-catalytic systems that combined with a transition metal to form a multiplex catalytic system and the well-established multiplex stereocenters of chiral aldehyde catalysis have been reviewed. Finally, a novel organocatalysis is prospected.

Highlights

Catalytic Asymmetric Amino Acid and Its Derivatives by Chiral Aldehyde CatalysisEdited by: Sreekantha Babu Jonnalagadda, University of KwaZulu-Natal, South Africa
In the last decades, the use of aldehyde catalysis is one of the most important and prevalent transformations in organic chemistry (Li et al, 2018; Wang et al, 2019; Yabushita et al, 2019)
Compared with binary catalytic systems, chiral aldehyde catalysts in ternary catalytic system acts as organic catalysts to activate amino acid and its derivatives through the formation of Schiff bases and acts as ligands to promote the nucleophilic attack process

Summary

Catalytic Asymmetric Amino Acid and Its Derivatives by Chiral Aldehyde Catalysis

Edited by: Sreekantha Babu Jonnalagadda, University of KwaZulu-Natal, South Africa. Specialty section: This article was submitted to Catalysis and Photocatalysis, a section of the journal Frontiers in Chemistry. Acid and Its Derivatives by Chiral Aldehyde Catalysis. Amine acid transformation is an important chemical process in biological systems. As a well-developed and acknowledged tool, chiral aldehyde catalysis provides good catalytic activation and stereoselective control abilities in the asymmetric reaction of N-unprotected amino acid esters and amino acid esters analogs, in which the key to success is the design of the catalysts derived from chiral BINOL aldehyde, which is based on the face control of enolate intermediates. One of the co-catalytic systems that combined with a transition metal to form a multiplex catalytic system and the well-established multiplex stereocenters of chiral aldehyde catalysis have been reviewed.

INTRODUCTION

Catalytic Asymmetric Amino Acid

CHIRAL ALDEHYDE CATALYSIS WITH TRANSITION METALS

CONCLUSION