Catalysts for Suzuki–Miyaura Coupling Reaction

Christophe Len

doi:10.3390/catal10010050

Abstract

Among the main reactions in organic chemistry, the Suzuki–Miyaura cross-coupling reaction catalyzed by a homogeneous or heterogeneous palladium complex is undoubtedly the most important [...]

Highlights

A review of the Suzuki–Miyaura cross-coupling reaction using nitroarenes as electrophilic coupling reagents instead of organic halides or triflates is reported [2]
The precatalyst (Pd 5 mol%) is obtained by the simultaneous reduction of graphene oxide (GRO) and PdCl2 in the presence of hydrazine hydrate as a reducing agent, while ammonium hydroxide is used as a source of “N” on the surface of graphene
In the presence of phenyl halides, phenyl boronic acids, and sodium dodecyl sulfate in refluxing water for 5 minutes, the cross-coupling affords the target biaryl derivatives in good yields

Summary

Introduction

A review of the Suzuki–Miyaura cross-coupling reaction using nitroarenes as electrophilic coupling reagents instead of organic halides or triflates is reported [2]. Nitrogen-doped graphene (NDG) is used as a support for the preparation of an NDG@Pd nanocatalyst in a Suzuki–Miyaura cross-coupling reaction [3]. In the presence of phenyl halides, phenyl boronic acids, and sodium dodecyl sulfate in refluxing water for 5 minutes, the cross-coupling affords the target biaryl derivatives in good yields.

Results

Conclusion