Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium

Abstract

A catalyst-free, one-pot method has been developed for the synthesis of isoindolin-1-imine derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and active methylene compound (1,3-dimethylbarbituric acid, Meldrum’s acid, 5,5-dimethylcyclohexane-1,3-dione, and 1,3-cyclohexanedione). The efficient and convenient reaction provides the corresponding products from various substrates at room temperature in aqueous medium with excellent yields (90–98 %) via easy purification. The straightforward procedure is a valid contribution to the methodology for the synthesis of isoindolin-1-imine derivatives.