Abstract
AbstractCatalyst-free biocompatible reactions are a class of green chemical processes that are also applicable to the field of chemical biology. In this account, we detail our journey in this exciting area of research since 2000. Various types of catalyst-free biocompatible reactions, such as the Mukaiyama aldol reactions and thiol-specific click reactions, and their applications to the functionalization of proteins are described. These reactions work well without destroying the three-dimensional structures of the proteins. Other reactions, including the C–SO2 and C–N bond-forming reactions, are also discussed. These reactions work in a truly green manner in which the use of organic solvents can be totally avoided. This toolbox of green chemical processes will certainly facilitate the work of researchers in the pharmaceutical industries.1 Introduction2 C–C Bond-Formation Reactions: The Mukaiyama Aldol Reaction3 C–S Bond-Formation Reactions: Allenic Amide as the Electrophiles4 C–SO2R Bond-Formation Reactions4.1 Allylic Alcohols as the Electrophiles4.2 Allenic Carbonyl Compounds as the Electrophiles5 C–N Bond-Formation Reactions6 Conclusions and Outlook
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
