Catalyst-free, one-pot synthesis of N,N-di(α-amino aryl ketones) from aryl glyoxals and aryl amines in presence of guanidine as a source of nitrogen

Abstract

Three-component reaction between aryl glyoxals, aryl amines, and guanidine afforded N,N-di (α-amino aryl ketone) derivatives. This method include two C–N bonds formation in a one-pot and single synthetic step in neutral and simple reaction conditions. All reactions were conducted in EtOH as solvent at reflux conditions without using any catalyst, and the stable products were obtained in high yields. The structures of all products were proved by 1H and 13C NMR, IR spectral and elemental analysis data.