Catalyst‐Free Hydrogen Proton Transfer Reduction of Nitrobenzamides to Aminobenzamides with iPrOH/KOH System

Abstract

AbstractA reduction of nitrobenzenes via the combination of KOH and isopropanol was established for the general synthesis of aniline derivatives. A metal catalyst isn't required in this alternative reduction reaction, and a series of nitrobenzamide compounds were chemoselectively reduced into the corresponding aminobenzamides in good to excellent yields. This reaction is operationally simple, and proceeds under mild conditions.