Abstract
An eco-friendly one-pot synthesis of polyhydroquinolines by four-component coupling of aldehydes, dimedone, ethylacetoacetate, and ammonium acetate using polyethylene glycol as a solvent at room temperature has been accomplished. The conversion was complete within 2–4 h, and the products were formed in high yields (83–95 %). No any additional catalyst was required. Several known and unknown polyhydroquinolines have been prepared. Some of the compounds exhibited impressive cytotoxic activity. A new multicomponent synthesis of polyhydroquinoline derivatives has been developed. The cytotoxic activity of some of the compounds is impressive.
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