Abstract
Abstract A new series of indeno[1,2-b]indol-5(4bH)-ylbenzimidamide derivatives 3a–3j has been synthesized as potential casein kinase II (CK2) inhibitors. A convenient and straightforward synthesis protocol was used via a reaction of β-enaminones 1a–1j with ninhydrin 2. This transformation proceeds under mild conditions (boiling ethanol, 0.5 h) in absence of catalyst in good to excellent yields (66–86%). The new compounds have been characterized by NMR, HRMS and IR spectra.
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