Catalyst-free decarboxylative alkylation: access to quaternary center

Abstract

The formation of C(sp3)−C(sp3) bonds has received continuous attention in organic synthesis, and the focus on versatile alkyl precursors remains constant. In our work, prevalent amines and carboxylic acids successfully serve as alkyl sources to construct C(sp3)−C(sp3) bonds via decarboxylative deamination. The catalyst-free decarboxylative alkylation reaction provides alternative access to the quaternary center. Primary mechanistic experiments suggest that it undergoes a polar mechanism.