Catalyst- and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels–Alder reaction strategy

Abstract

2,4-Disubstituted tetrahydroquinazolines can be readily obtained via a four-component aza-Diels–Alder reaction inside a microwave reactor. The methodology developed is simple, catalyst- and solvent-free and can be tuned to get dihydroquinazoline derivatives.