Catalase and Superoxide Dismutase (SOD) activity in Swiss Albino mice treated with Ethanolic leaf extract of Bauhinia variegata

Abstract

The leaves of Bauhinia variegata were found crucial for the cure of many diseases. Many of its uses have not been found yet. This research was conducted to investigate the antioxidant activity of the ethanolic extract of dried leaves of Bauhinia variegata in swiss albino mice. A total of forty eight (48) adult swiss albino mice were used. The mice were placed into eight groups: 1,2,3,4,5,6,7 and 8. Each of the groups contained six mice. Groups 4 and 5 were treated orally with doses of 200 and 400 mg/kg body weight of the ethanolic extract respectively for 28 consecutive days. Group 1 was the control group and was fed only distilled water and feed. The catalase and superoxide dismutase (SOD) activity obtained in the test groups were significantly higher (P>0.05) than that of the control mice. The observations recorded from this research were dose dependent. The observations of the present research may be utilized to enhance the nootropic and antioxidant activity and can be used for treatment of various diseases.