Castleman Hastalığı: Nadir Intraabdominal Yerleşim Nedeniyle

Mehmet Cihan Karacaoğlu ,Betül Kızıldağ,Turgay Kara,Nursel Yurttutan,Sezen Koçarslan

doi:10.5222/forbes.2021.66376

Abstract

Castleman disease (CD) is a rare benign disease with unknown etiology. It is also called angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, lymph node hamartoma, benign giant lymphoma. Histologically, it is classified as hyaline vascular and plasma cell variant, but rarely features of two types can coexist. Most of the cases with unisentric disease are hyaline vascular and most of the cases with multicentric disease are in plasma cell histological type. Although it is frequently located in thorax, it can be found throughout the body. Salivary glands, lungs, pancreas, larynx, parotid gland, meninges, and even limb muscles can be affected as extralymphatic spread. Since it is localized in the middle and anterior mediastinum in the thorax, it should be differentiated from mediastinal autoimmune and neoplastic diseases. In this case report, we aimed to present the radiological findings of a CD case with a rare intraabdominal location.

Highlights

Castleman Disease (CD) was firstly described in 1956 as “localized mediastinal lymph node hyperplasia resembling thymoma”.1 Later, the definition was expanded and extramediastinal lymph nodes and spleen were included in the definition.[2] more than 70% of cases are located in the mediastinum or hilus in the thorax, it can rarely localize in the neck, pelvis, pleura, muscle, retroperitoneal region, abdomen and axillary region.[2,3,4]It is a rare disease with two histological types defined as hyaline-vascular and plasmocellular CD
More than 70% of cases are located in the mediastinum or hilus in the thorax, it can rarely localize in the neck, pelvis, pleura, muscle, retroperitoneal region, abdomen and axillary region.[2,3,4]
We aimed to present the computed tomography (CT) findings and histopathological features of an intraabdominal CD case which was confirmed by total excisional biopsy

Summary

INTRODUCTION

Castleman Disease (CD) was firstly described in 1956 as “localized mediastinal lymph node hyperplasia resembling thymoma”.1 Later, the definition was expanded and extramediastinal lymph nodes and spleen were included in the definition.[2]. More than 70% of cases are located in the mediastinum or hilus in the thorax, it can rarely localize in the neck, pelvis, pleura, muscle, retroperitoneal region, abdomen and axillary region.[2,3,4] It is a rare disease with two histological types defined as hyaline-vascular and plasmocellular CD. A wellcircumscribed, round,soft tissue mass with dimensions of 35 x 32 x 41 mm (transverse x anteroposterior x craniocaudal diameters) adjacent to the mesenteric vascular structures, and demonstrating significant homogeneous contrast enhancement (mean HU=146.3) in the portal venous phase after intravenous injection of non ionic iodinated contrast agent (2 cc/kg), was detected in the upper left quadrant of the abdomen (Figure 1). The patient was evaluated by abdominal US examination and no mass lesion was detected.

DISCUSSION

Findings

CONCLUSION