Abstract
Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old woman were detected to have a pancreatic mass in the routine medical examinations. Both of them were asymptomatic. The computed tomography and ultrasonographic examination revealed a mild enhancing solitary mass at the pancreatic head/neck. No definite preoperative diagnosis was established and Whipple operations were originally planned. The intraoperative frozen section diagnosis of both patients revealed lymphoproliferation. Then the local excisions of mass were performed. Histological examination revealed features of CD of hyaline-vascular type. No recurrence was found during the follow-up period. CD should be included in the differential diagnosis of pancreatic tumors. Local excision is a suitable surgical choice.
Highlights
Castleman disease (CD) is an uncommon benign lymphoproliferative disorder of unknown etiology
There are three pathologic variants: hyaline vascular CD, plasma cell CD, and mixed type of CD is characterized that a patient had features of both hyaline vascular and plasma cell types of CD [2]
Plasmablastic variant of CD, which was considered as a subvariant of plasma cell type, occurs predominantly in immunosuppressed patients and human immunodeficiency virus (HIV)-positive patients [3]
Summary
Castleman disease (CD) is an uncommon benign lymphoproliferative disorder of unknown etiology. The unicentric variant of CD (UCD) is the most common form of the disease, which is confined to a single lymph-node chain or area, with hyaline vascular type. It is often asymptomatic and curable by surgical excision of the mass. Case 2: a 58-year-old woman with no remarkable medical history visited our hospital with a mass detected by ultrasonographic examination in a routine examination The image findings revealed a mass in pancreas, preoperative tumor marker CA 19–9 were slightly elevated. Both were mimicked carcinoma of pancreas, and Whipple operations were planned before the operation. The tumor markers were reexamined 1month after the operation, and the CA 19–9 in both patients were within normal range
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