Abstract
Castleman disease is a benign lymphoproliferative disorder of unknown etiology, more commonly appearing in the mediastinum. Craniofacial involvement is rare. Surgical excision is the only intervention needed for the unicentric type, while systemic treatment would be necessary for the multicentric type. Here, we report a rare case of unicentric castleman disease of the buccal space of a 23-year-old woman. Additionally, we review the radiological and histopathological features of this lesion.
Highlights
Castleman disease (CD) is an infrequent lymphoproliferative disorder with an unknown etiology
We report a rare case of unicentric castleman disease of the buccal space of a 23-year-old woman
Unicentric CD, the more frequent type, is defined as a localized lymphadenopathy, while multicentric CD has systemic manifestations such as flulike symptoms and multiple lymphadenopathies probably associated with high cytokine levels
Summary
Castleman disease (CD) is an infrequent lymphoproliferative disorder with an unknown etiology. It is a lymphadenopathy with specific histologic characteristics and is generally benign. The clinical manifestations can be categorized into two groups: unicentric (localized) and multicentric (systemic) (1). Unicentric CD, the more frequent type, is defined as a localized lymphadenopathy, while multicentric CD has systemic manifestations such as flulike symptoms and multiple lymphadenopathies probably associated with high cytokine levels. It is believed that there is a strong relationship between multicentric CD and HIV or HHV-89 (2). We describe a rare case of unicentric CD with presentation of a mass located in the buccal space that was completely excised
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