Cassia tora L. Creams Inhibit Psoriasis in Mouse Tail Model

Abstract

The aim of this study was to determine the anti-psoriatic activity of newly formulated oil in water (O/W) creams of methanol extract of Cassia tora L. leaves using Mouse tail model. The plant C. tora has been traditionally used in the treatment of number of skin diseases. However, there is no established scientific evidence reported for its anti- psoriatic activity. Methanol extract of C. tora leaves was prepared as various concentrations of O/W creams and tested for acute dermal toxicity study. The different O/W creams showed good physical characteristics and pass the sensitivity, irri- tation, grittiness and bleeding test. The results of acute dermal toxicity study showed that the creams were safe up to the dose of 2,000 mg/kg. In the case of Mouse tail model, histopathological analysis revealed that there were absence of Munro micro abscess, elongation of rete ridges and capillary loop dilation in the sections in Test 2 (0.1%) and Standard group. O/W creams and methanol extract of C. tora leaves exhibited significant reduction in percentage relative epidermal thickness and spleen index as compared to the positive control. We concluded that topical O/W creams and crude extact containing mehthanolic extract of C. tora leaves has potent anti-psoriatic activity.