Abstract
Detailed phytochemical investigation of the roots of Erythrophleum fordii furnished seven undescribed cassane-type diterpenoids, erythrocassanoids A-E and erythro-norcassanoids A, B and two known clerodane diterpenes, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid. Their structures were determined by 1D, 2D NMR and HRESIMS analysis. The antiviral activities of these compounds were evaluated. Among them, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid showed antiviral activities against influenza virus and coxsackie virus with IC50 values ranging from 11.11 to 29.60 μM.
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